ANNOUNCEMENT: We are undergoing a transformation! The California MAT Expansion Project will be changing to California Opioid Response.
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California Substance Use Line

Free, confidential, 24/7 guidance on substance use evaluation and management for California health care providers

The California Substance Use Line (CSUL) is a round-the-clock, cost-free tele-consultation service for substance use evaluation and management that is available to all California clinicians in any health care setting. Supported by DHCS funding through the California MAT Expansion Project, the CSUL is a unique collaboration between the California Poison Control System (CPCS) and the Clinician Consultation Center (CCC) at the University of California, San Francisco. Together, this partnership brings over 25 years of experience helping a broad range of clinicians provide evidence-based care. Consultants offer expert clinical depth across multiple domains, including toxicology, medications for substance use disorders, polysubstance use, behavioral health, harm reduction, HIV, viral hepatitis, and primary care.

Our teams are positioned to complement the other activities operating under DHCS’ MAT Expansion Project by offering on-demand, 24/7 assistance to clinicians of any level of experience. Our expert physicians, clinical pharmacists, and advanced practice nurses are standing by to provide evidence-based guidance and clinical decision support on evaluation and management of opioid, alcohol, and other substance use. We can help clinicians by:

  • Providing point-of-care assistance — no matter how basic or complex the scenario — and helping to guide treatment planning.
  • Building skills, capacity, and confidence with substance use management or treatment, including connecting callers with general information and resources.
  • Guiding development and implementation of protocols for opioid overdose/withdrawal and its aftercare.
  • Welcoming follow-up calls for continued conversations.

Our team is excited to be a part of DHCS’ MAT Expansion Project and hopes to complement the other California resources to build a robust and supportive care delivery system for people who use substances. We welcome any opportunities to collaborate with our partners in California to support your project’s needs. Please visit our website or contact Zeb Kessler at to learn more about the service and how it could fit into your project.